Can Cannabidiol Help Prevent and Treat Gastrointestinal Disorders? Insights from Experts

Numerous individuals look for a “cannabis store near me” to acquire marijuana, whether for alleviating their condition or for leisure use. It’s widely recognized that cannabis products may assist in alleviating issues like anxiety, depression, pain, nausea, and vomiting. Have you ever thought about its impact on gastrointestinal disorders?

Key Takeaways:

• Cannabinoids in the cannabis engage with the endocannabinoid system in the GI tract.
• cannabis and pain relief medications can aid in managing Irritable Bowel Syndrome symptoms.
• cannabis Sativa has various uses, but it’s primarily known for its recreational and medicinal benefits.

Gastrointestinal Disorders and Bloom Supply Canada

The dietary benefits of nutraceuticals on GI health are well-recognized. Certain diets can potentially prevent or alleviate various GI disorders. Researchers have identified and assessed food components responsible for these advantages.

Among plant-derived nutraceuticals, those from cannabis show promise in treating GI issues. cannabis refers to products derived from the cannabis Sativa plant, a fragrant annual flowering herb.

John M. McPartland concluded in a scientific review that the Cannabaceae family includes the genera Cannabis, Humulus, and Celtis. Within the cannabis genus, sativa has three varieties: Sativa, Indica, and Ruderalis. Depending on the variety, cannabis serves multiple purposes, including fiber production, oil extraction from seeds, and, primarily, recreational or medicinal applications.

The Impact of cannabis

The endocannabinoid system’s receptors and ligands are distributed throughout various areas and systems, both within and beyond the GI tract, essential for regulating GI functions. The presence of cannabinoid receptors means cannabinoids, including non-psychoactive phytocannabinoids, help modulate GI functions across health and disease. The ECS plays a role in regulating motility, secretion, epithelial barrier function, and viscerosensitivity.

Irritable Bowel Syndrome (IBS)

IBS has several contributing factors and affects 10–20% of individuals in developed countries. It presents as functional gastrointestinal disturbances without identifiable organic causes.

The enhancement of the antinociceptive properties of cannabinoids in the presence of inflammation highlights the ECS’s significance in visceral hypersensitivity. This discovery not only clarifies the mechanisms behind conditions like IBS and other GI disorders but also suggests promising treatment pathways for alleviating abdominal and visceral pain.

Cannabinoids alone may not provide substantial relief in reducing visceral hypersensitivity among IBS patients. Exploring combinations with other pain-modulating agents, like opioids, offers an intriguing alternative worth exploring.

Inflammatory Bowel Disease (IBD)

IBD, including Crohn’s disease (CD) and ulcerative colitis (UC), is a complex GI condition. These disorders arise from environmental, genetic, and epigenetic factors.

Cannabidiol exhibits significant anti-inflammatory effects across various intestinal inflammation models in mice and rats, as indicated in a study in the Journal of Frontiers in Pharmacology. Both local and systemic administration of CBD demonstrated a dose-dependent improvement in disease indicators:

• The reduction of structural damage
• The mitigation of inflammation-related increases in various cytokines, chemokines, and oxidative stress markers.

A study from the Inflammatory Diseases Journal reported that the primary finding of their investigation was the challenging tolerability of the botanical extract, with 90% of patients noting treatment-related adverse effects compared to 48% receiving the placebo.

A tendency toward improved quality of life scores and a positive shift in patients’ overall impression of change emerged from the per-protocol analysis. The authors speculate that the CBD-rich botanical extract may offer therapeutic advantages to those who can tolerate its effects.

Gastrointestinal Cancer

GI cancers, particularly colorectal cancer (CRC), are among the most frequently diagnosed conditions in the general population.

Numerous studies have demonstrated CBD’s antiproliferative effects in colorectal cancer models. CBD can protect DNA from oxidative stress, elevate endocannabinoid levels, and inhibit the growth of colorectal cancer cells in vitro.

The confirmation of CBD’s chemopreventive properties emerged from in vivo models focusing on AOM-induced colon cancer. A dosage of 1 mg/kg of CBD led to a notable reduction: ACF decreased by 67%, while the number of tumors and polyps fell by 66% and 57%, respectively. Increasing the dosage to 5 mg/kg showed efficacy mainly in preventing polyp formation.

THC induces apoptosis in colorectal cancer cells by activating the CB1 receptor.

Nausea and Vomiting

Positive effects of CBD occur when combined with THC, as suggested in a study in the British Journal of Clinical Pharmacology. CBD’s anti-nausea and anti-emetic properties may arise from the indirect stimulation of somatodendritic 5-HT1A receptors in the dorsal raphe nucleus, potentially leading to a decrease in the release of 5-HT in specific forebrain areas.

Gastroesophageal Reflux Disease (GERD)

Cannabinoids reduce transient LES relaxations through a CB1-dependent mechanism in both dogs and ferrets, as highlighted in a study from the Journal of cannabis and Cannabinoid Research. These findings are significant, as transient LES relaxations are the primary mechanism underlying gastroesophageal reflux disease.

cannabis for GI Issues

Conclusion

Numerous studies indicate that the advantages of cannabinoids extend beyond the well-known psychoactive compound THC to include non-psychoactive molecules like CBD and others, which have received relatively less attention. The cannabis plant influences the GI system by interacting with the ECS to stimulate multiple functions that can aid in managing symptoms of certain GI conditions.

Frequently Asked Questions

What can you expect when buying from online Bloom Supply Canada?

1. Accessing your cannabis products in Canada from an online store provides numerous options featuring both classic favorites and new products.
2. Expect additional benefits such as special offers, reliable payment methods, and shipping options covering most provinces.
3. Essential resources, including a blog section or contact page, are available to offer insights or assistance during your shopping experience.
4. As part of the purchasing process, you’ll need to verify your age by presenting identification.
5. Some stores include taxes in their products’ total price, while others calculate it during checkout.
6. Some dispensaries accept online payments like Interac E-Transfer, while others allow cash on delivery.

What is the measurement unit when buying from a Bloom Supply Canada?

There are two primary measurement forms: metric and imperial units. On a Bloom Supply Canada, you’ll find measurements in grams or ounces, allowing you to locate products like 3.5 grams or 1/8 ounces.

What distinguishes cannabis for medical use from that used recreationally?

Medical cannabis and recreational cannabis come from the same plant species, yet their differing effects and intended uses differentiate them. Medical cannabis acts as a therapeutic aid for specific health conditions, with a higher CBD content compared to its recreational counterpart.

Are there ready-made joints available in a Bloom Supply Canada?

Yes. These are available as pre-rolls. cannabis pre-rolls, or pre-rolled joints and blunts, are convenient choices for those who prefer ready-to-use cannabis. The popularity of pre-rolled joints infused with cannabis concentrates is on the rise.

Do Bloom Supply Canada have a physical store?

Not all online stores have physical locations, meaning you can receive your purchases directly at your doorstep rather than needing to pick them up from a physical store after placing an online order.